A Simon Selected Research

Immunoglobulin D (IgD)

5/2008	Lovastatin inhibits formation of AA amyloid.
7/2005	Effect of etanercept and anakinra on inflammatory attacks in the hyper-IgD syndrome: introducing a vaccination provocation model.
6/2005	Serum amyloid A serum concentrations and genotype do not explain low incidence of amyloidosis in Hyper-IgD syndrome.
9/2004	Effect of inflammatory attacks in the classical type hyper-IgD syndrome on immunoglobulin D, cholesterol and parameters of the acute phase response.
3/2004	Mevalonate kinase deficiency: Evidence for a phenotypic continuum.
9/2001	Molecular analysis of the mevalonate kinase gene in a cohort of patients with the hyper-igd and periodic fever syndrome: its application as a diagnostic tool.
9/2001	Limited efficacy of thalidomide in the treatment of febrile attacks of the hyper-IgD and periodic fever syndrome: a randomized, double-blind, placebo-controlled trial.
4/2001	Molecular analysis of MVK mutations and enzymatic activity in hyper-IgD and periodic fever syndrome.

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A Simon Research Topics

Disease

19	Infections 05/2022 - 01/2000
18	Neoplasms (Cancer) 10/2019 - 03/2001
15	Fever (Fevers) 07/2017 - 01/2001
7	Inflammation (Inflammations) 08/2015 - 06/2005
7	Mevalonate Kinase Deficiency 07/2015 - 04/2001
5	Bacterial Infections (Bacterial Infection) 12/2013 - 09/2001
5	Cystic Fibrosis (Mucoviscidosis) 08/2009 - 09/2005
4	Head and Neck Neoplasms (Head and Neck Cancer) 10/2018 - 12/2011
4	Prostatic Neoplasms (Prostate Cancer) 07/2016 - 09/2009
4	Virus Diseases (Viral Diseases) 12/2013 - 04/2000
4	Pneumonia (Pneumonitis) 10/2011 - 11/2005
4	Atherosclerosis 10/2010 - 02/2001
4	Amyloidosis 05/2009 - 06/2005
4	Hypertension (High Blood Pressure) 01/2009 - 07/2000
3	Exanthema (Rash) 07/2017 - 12/2012
3	Hepatitis C 12/2015 - 04/2006
3	Fibrosis (Cirrhosis) 12/2015 - 03/2006
3	Sepsis (Septicemia) 12/2013 - 10/2006
3	Cardiovascular Diseases (Cardiovascular Disease) 10/2010 - 11/2001
3	Cross Infection (Nosocomial Infection) 05/2010 - 01/2000
3	Breast Neoplasms (Breast Cancer) 03/2010 - 12/2001
2	Disease Progression 01/2021 - 10/2000
2	Heart Failure 12/2020 - 09/2000
2	Atrial Fibrillation 01/2020 - 01/2017
2	Uterine Cervical Neoplasms (Cancer of the Cervix) 01/2019 - 09/2012
2	Psychotic Disorders (Schizoaffective Disorder) 03/2018 - 08/2012
2	Critical Illness (Critically Ill) 07/2017 - 09/2002
2	Carcinoma (Carcinomatosis) 06/2016 - 10/2015
2	Neutropenia 05/2015 - 11/2005
2	Communicable Diseases (Infectious Diseases) 12/2013 - 11/2005
2	Renal Cell Carcinoma (Grawitz Tumor) 03/2010 - 05/2008
2	Respiratory Insufficiency (Respiratory Failure) 08/2009 - 04/2008
2	Lymphadenopathy 12/2008 - 09/2004
2	Febrile Neutropenia 11/2007 - 06/2001
2	Hepatocellular Carcinoma (Hepatoma) 08/2006 - 08/2001
2	Endocarditis 07/2006 - 11/2005
2	Osteomyelitis 07/2006 - 11/2005
2	Thrombosis (Thrombus) 07/2006 - 11/2005
2	Polyneuropathies (Polyneuropathy) 04/2006 - 09/2001
2	Necrosis 12/2005 - 01/2001
2	Atherosclerotic Plaque (Atheroma) 02/2001 - 11/2000
1	Surgical Wound 05/2022
1	Dysbiosis 01/2022
1	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (Leukemia, Pre B Cell) 01/2022
1	Malnutrition (Nutritional Deficiencies) 01/2021
1	Hypotension (Low Blood Pressure) 01/2020
1	Cardiogenic Shock 01/2020

Drug/Important Bio-Agent (IBA)

8	Immunoglobulin D (IgD)IBA 05/2008 - 04/2001
6	Anti-Bacterial Agents (Antibiotics)IBA 01/2022 - 09/2001
5	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 01/2013 - 07/2005
4	DNA (Deoxyribonucleic Acid)IBA 07/2017 - 10/2000
4	Proteins (Proteins, Gene)FDA Link 08/2015 - 03/2000
4	mevalonate kinaseIBA 07/2015 - 04/2001
4	CholesterolIBA 08/2006 - 08/2001
3	RNA (Ribonucleic Acid)IBA 12/2015 - 12/2006
3	EnzymesIBA 01/2014 - 03/2001
3	AA amyloidosisIBA 01/2013 - 04/2007
3	LipidsIBA 10/2010 - 02/2001
2	Local Anti-Infective Agents (Antiseptics)IBA 05/2022 - 09/2007
2	Pharmaceutical PreparationsIBA 01/2020 - 10/2016
2	Penicillins (Penicillin)FDA Link 05/2016 - 09/2001
2	Protease Inhibitors (Protease Inhibitor)IBA 12/2015 - 01/2014
2	C-Reactive ProteinIBA 12/2013 - 01/2007
2	Galectin 3 (LGALS3)IBA 12/2013 - 03/2010
2	Biological ProductsIBA 01/2013 - 05/2005
2	Antipsychotic Agents (Antipsychotics)IBA 08/2012 - 07/2004
2	SteroidsIBA 10/2011 - 02/2002
2	AntioxidantsIBA 10/2010 - 03/2001
2	Serum Amyloid A Protein (Serum Amyloid A)IBA 05/2009 - 06/2005
2	Amyloid (Amyloid Fibrils)IBA 05/2009 - 05/2008
2	Fibrinogen (Factor I)FDA Link 01/2009 - 07/2000
2	CalciumIBA 01/2009 - 03/2000
2	AntigensIBA 12/2006 - 04/2006
2	Thalidomide (Thalomid)FDA Link 04/2006 - 09/2001
2	Etanercept (Enbrel)FDA Link 12/2005 - 07/2005
2	Intravenous Immunoglobulins (IVIG)FDA Link 02/2002 - 01/2002
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 11/2001 - 03/2001
2	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 11/2001 - 01/2001
2	CytokinesIBA 03/2001 - 10/2000
1	Povidone-Iodine (Betadine)FDA LinkGeneric 05/2022
1	Sarcoplasmic Reticulum Calcium-Transporting ATPasesIBA 12/2020
1	Protein Isoforms (Isoforms)IBA 12/2020
1	vernakalantIBA 01/2020
1	AntipyreticsIBA 07/2017

Therapy/Procedure

11	Therapeutics 12/2015 - 06/2001
10	Radiotherapy 10/2019 - 09/2012
6	Lung Transplantation 01/2016 - 04/2008
5	Intensity-Modulated Radiotherapy (Radiotherapy, Intensity Modulated) 10/2018 - 12/2011
5	Drug Therapy (Chemotherapy) 03/2018 - 11/2005
4	Catheters 05/2022 - 02/2008
4	Central Venous Catheters 05/2016 - 01/2000
3	Critical Care (Surgical Intensive Care) 07/2017 - 01/2000
3	Stem Cell Transplantation 05/2015 - 11/2005
2	Antibiotic Prophylaxis 05/2016 - 06/2008
2	Ventriculoperitoneal Shunt 02/2008 - 09/2001
2	Duration of Therapy 07/2006 - 11/2005
1	Injections 05/2022
1	Hematopoietic Stem Cell Transplantation 01/2021
1	Heart-Assist Devices 12/2020
1	Brachytherapy 01/2019